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ENZO ▼Y-27632 . dihydrochloride


ENZO ▼Y-27632 . dihydrochloride	브랜드	ENZO
	품명	Y-27632 . dihydrochloride
	CAT. NO	ALX-270-333-M005	분류	inhibitor
	규격	5mg	재고	STOCK
	소비자가(₩)		CAS. NO
	온도	-20℃	위험물
	수입발주일	매주 목요일 오후 5시
	주의사항

Information
Y-27632 is a highly potent, cell permeable, ive and ATP competitive inhibitor of ROCK1 and ROCK2 (IC₅₀=800nM). It acts as a potent inhibitor of agonist-induced Ca²⁺sensitization of myosin phosphorylation and smooth muscle contractions, blocking cell spreading and suppresses RhoA-induced formation of stress fibers in hepatic stellate cells. Y-27632 significantly reduces the increase of inflammatory cytokines after reperfusion, preventing the development of acute renal failure. There are numerous application for this compound including: cardioprotective effects, suppression of tumor cell invasion, inhibition of superoxide production, mimicking effect of β-agonists on human cells, and an antinociceptive effect. There has been a growing interest in Y-27632 for use in stem cell self-renewal and reprogramming. It is known to increase the survival rate of human embryonic stem cells undergoing cryopreservation.

Alternative Name:
(R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide . 2HCl

Formula: C₁₄H₂₁N₃O . 2HCl

MW: 247.3 . 73.0

CAS: 129830-38-2

Purity: ≥98% (HPLC (UV))

Purity Detail: Enantiomeric excess ≥96%

Identity: Determined by MS, ¹H- and ¹³C-NMR.

Appearance: White to pale yellow powder.

Solubility: Soluble in DMSO (25mg/ml), methanol (25mg/ml), acetonitrile (<1mg/ml), dioxan (<1mg/ml), water (very soluble).

Shipping: Ambient

Long Term Storage: -20°C

Use/Stability: Stock solutions are stable for up to 1 month when stored at -20°C.

Handling:
Protect from light. Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C.

Datasheet / MSDS

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Alternative Name:	(R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide . 2HCl

Formula:	C₁₄H₂₁N₃O . 2HCl

MW:	247.3 . 73.0

CAS:	129830-38-2

Purity:	≥98% (HPLC (UV))

Purity Detail:	Enantiomeric excess ≥96%

Identity:	Determined by MS, ¹H- and ¹³C-NMR.

Appearance:	White to pale yellow powder.

Solubility:	Soluble in DMSO (25mg/ml), methanol (25mg/ml), acetonitrile (<1mg/ml), dioxan (<1mg/ml), water (very soluble).

Shipping:	Ambient

Long Term Storage:	-20°C

Use/Stability:	Stock solutions are stable for up to 1 month when stored at -20°C.

Handling:	Protect from light. Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C. Datasheet / MSDS