ENZO ▼Y-27632 . dihydrochloride

ENZO ▼Y-27632 . dihydrochloride

브랜드 ENZO
품명 Y-27632 . dihydrochloride
CAT. NO ALX-270-333-M005 분류 inhibitor
규격 5mg 재고 STOCK
소비자가(₩) 279,000 CAS. NO
온도 -20℃ 위험물
수입발주일 매주 목요일 오후 5시

Y-27632 is a highly potent, cell permeable, ive and ATP competitive inhibitor of ROCK1 and ROCK2 (IC50=800nM). It acts as a potent inhibitor of agonist-induced Ca2+sensitization of myosin phosphorylation and smooth muscle contractions, blocking cell spreading and suppresses RhoA-induced formation of stress fibers in hepatic stellate cells. Y-27632 significantly reduces the increase of inflammatory cytokines after reperfusion, preventing the development of acute renal failure. There are numerous application for this compound including: cardioprotective effects, suppression of tumor cell invasion, inhibition of superoxide production, mimicking effect of β-agonists on human cells, and an antinociceptive effect. There has been a growing interest in Y-27632 for use in stem cell self-renewal and reprogramming. It is known to increase the survival rate of human embryonic stem cells undergoing cryopreservation. 

Alternative Name:

(R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide . 2HCl

Formula:C14H21N3O . 2HCl
MW:247.3 . 73.0
Purity:≥98% (HPLC (UV))
Purity Detail:Enantiomeric excess ≥96%
Identity:Determined by MS, 1H- and 13C-NMR.
Appearance:White to pale yellow powder.
Solubility:Soluble in DMSO (25mg/ml), methanol (25mg/ml), acetonitrile (<1mg/ml), dioxan (<1mg/ml), water (very soluble).
Long Term Storage:-20°C
Use/Stability:Stock solutions are stable for up to 1 month when stored at -20°C.

Protect from light. Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C.




Datasheet / MSDS 



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