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ENZO ▼MG-132

ENZO ▼MG-132

브랜드 ENZO
품명 MG-132
CAT. NO BML-PI102-0005 분류 inhibitor
규격 5mg 재고 STOCK
소비자가(₩) 148,000 CAS. NO
온도 -80℃ 위험물
수입발주일 매주 목요일 오후 5시
주의사항

Infotmation
MG-132 is a potent, cell permeable and ive proteasome inhibitor (Ki = 4nM).1 It inhibits NF-κB activation by preventing IκB degradation (IC50 = 3μM). The peptide blocks degradation of short-lived proteins, which in turn induces HSP and ER chaperone expression, leading to thermotolerance (1μM MG-132, 2 h.). It also stimulates neurite outgrowth in PC12 cells (20nM optimal). The peptide has also been reported to increase the survival rate of mesenchymal stem cells following their transplantation. IC50’s for inhibition of Suc-LLVY-AMC and Z-LLL-AMC cleaving activities of proteasome were 0.85 and 0.1μM respectively. The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems, thus blockade of UPS by MG-132 activates autophagy.
 

Alternative Name:Z-LLL-CHO
 
Sequence:Z-Leu-Leu-Leu-CHO
 
Formula:C26H41N3O5
 
MW:475.6
 
CAS:133407-82-6
 
Purity:≥98%
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Use/Stability:

Solutions are stable for up to one week if stored at -20°C. Solutions are stable for up to two months if stored at -80°C.

 

 

 

Datasheet / MSDS 

 

 

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