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ENZO ▼Microcystin-LR

ENZO ▼Microcystin-LR

 브랜드 ENZO
품명 Microcystin-LR
CAT. NO ALX-350-012-C100 분류 Biochemical
규격 100μg 재고 -
소비자가(₩) CAS. NO
온도 -20℃ 위험물
수입발주일 매주 목요일 오후 5시
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Heptapeptide ester hepatotoxin. Tumor promoter. Equally potent and ive inhibitor of protein phosphatase 1 (PP1) and 2A (PP2A). PP2B is less sensitive and PP2C is not inhibited up to 4µM. Useful for affinity-purification of PP2A. The product is not cell permeable except in liver cells, which appear to have a functional uptake system. Is absorbed by hepatocytes viathe multispecific organic anion transporter. Does not induce any effects on mouse skin or human fibroblasts due to cell membranes impermeability. Has no effect on protein kinases. Less toxic than the more hydrophobic analogs microcystin-LY, -LW and -LF. Frequently contaminates fresh-water lakes and ponds. Causes livestock poisonings. Ozonation did lead to complete loss of toxicity and toxins from contaminated samples.


Formula:C49H74N10O12
 
MW:995.2
 
Source:Isolated from Microcystis aeruginosa.
 
CAS:101043-37-2
 
RTECS:GT2810000
 
Purity:≥95% (HPLC)
 
Identity:Identity determined by MS.
 
Appearance:Whitish film adhered to inside of the vial.
 
Solubility:Soluble in 100% ethanol, methanol or DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stock solutions are stable for up to 6 months when stored at -20°C. Unstable at pH>7.7.
 
Handling:For maximum product recovery after thawing, centrifuge the vial before opening the cap.
 

Scientific Background:





Microcystins are a group of cyclic heptapeptide hepatotoxins produced by a number of cyanobacterial genera. The most notable of which, and namesake, is the widespread genus Microcystis. Structurally, all microcystins consist of the generalized structure cyclo(-D-Ala1-X2-D-MeAsp3-Y4-Adda5-D-Glu6-Mdha7-). X and Y are variable L-amino acids, D-MeAsp is D-erythro-β-methylaspartic acid and Mdha is N-methyldehydroalanine. Adda is the cyanobacteria unique C20 β-amino acid 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid. Substitutions of the variable L-amino acids at positions 2 and 4 give rise to at least 21 known primary microcystin analogs and alterations in the other constituent amino acids result in more than 90 reported mycrocystins to date.

 

 

 

Datasheet / MSDS 

 

 

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