ENZO ▼Microcystin-RR
ENZO ▼Microcystin-RR |
브랜드 | ENZO | |
---|---|---|---|
품명 | Microcystin-RR | ||
CAT. NO | ALX-350-043-C100 | 분류 | Biochemical |
규격 | 100μg | 재고 | - |
소비자가(₩) | CAS. NO | ||
온도 | -20℃ | 위험물 | |
수입발주일 | 매주 목요일 오후 5시 | ||
주의사항 | 용도설명서 작성 필수 |
Information
Arg-Arg analog of microcystin-LR (Prod. No. ALX-350-012). Hepatotoxic, although found to be up to 10-fold less toxic than microcystin-LR on i.p. injection in mice. Potent inhibitor of protein phosphatase 2A (PP2A).
Formula: | C49H75N13O12 |
MW: | 1038.2 |
Source: | Isolated from Microcystis aeruginosa. |
CAS: | 111755-37-4 |
Purity: | ≥95% (HPLC) |
Identity: | Identity determined by MS. |
Appearance: | Clear to whitish film adhered to inside of vial. |
Solubility: | Soluble in 80% aqueous methanol. |
Shipping: | Ambient |
Long Term Storage: | -20°C |
Handling: | For maximum product recovery after thawing, centrifuge the vial before opening the cap. |
Scientific Background: | Microcystins are a group of cyclic heptapeptide hepatotoxins produced by a number of cyanobacterial genera. The most notable of which, and namesake, is the widespread genus Microcystis. Structurally, all microcystins consist of the generalized structure cyclo(-D-Ala1-X2-D-MeAsp3-Y4-Adda5-D-Glu6-Mdha7-). X and Y are variable L-amino acids, D-MeAsp is D-erythro-β-methylaspartic acid and Mdha is N-methyldehydroalanine. Adda is the cyanobacteria unique C20 β-amino acid 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid. Substitutions of the variable L-amino acids at positions 2 and 4 give rise to at least 21 known primary microcystin analogs and alterations in the other constituent amino acids result in more than 90 reported mycrocystins to date.
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