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BPS ▼Human TDO Inhibitor Screening Assay Kit

BPS ▼Human TDO Inhibitor Screening Assay Kit

브랜드 BPS
품명 Human TDO Inhibitor Screening Assay Kit
CAT. NO 72023 분류 assay kit
규격 96 reactions 재고 -
소비자가(₩) 1,450,000 CAS. NO
온도 -80℃ R.T. 위험물
수입발주일 목요일 오후 5시
주의사항
Background:
L-tryptophan (L-Trp) is an essential amino acid necessary for protein synthesis in mammalian cells and the L-Trp to kynurenine (Kyn) pathway is firmly established as a key regulator of innate and adaptive immunity. Catabolism of L-Trp to Kyn maintains an immunosuppressive microenvironment by starving immune cells of L-Trp and releasing degradation products of L-Trp that have immunosuppressive functions. Tryptophan 2,3 dioxygenase (TDO) is upregulated in many tumors, providing cancer cells with an avenue for immune evasion.
Information:

The TDO Inhibitor Screening Assay Kit is designed to measure TDO enzyme inhibition. The kit comes in a convenient format, with enough reaction solution and enzyme to perform a total of 100 reactions. The TDO Inhibitor Screening Assay Kit is simple to use. Inhibitor and enzyme are added to a sample containing L-Trp substrate. After a room temperature incubation activity is measured by measuring the absorption of reaction product at  λ = 320-325 nm.

Synonym(s):
TDO2, tryptophan 2,3 dioxygenase
Format:

COMPONENTS:

Instructions for use:
See product datasheet for detailed protocol.
Storage / Stability:
Stable at least 6 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival.
Application(s):
Useful for the study of TDO enzymology, screening inhibitors and ivity profiling.
Reference(s):
Li, J.S., et al. Arch Insect Biochem Physiol. 2007 Feb; 64(2): 74–87
Notes:

MATERIALS OR INSTRUMENTS REQUIRED BUT NOT SUPPLIED: 
Spectrophotometer capable of measuring absorbance at  = 320-325 nm.

Warning(s):

DMSO >0.5%, strong acids or bases, ionic detergents, high salt
Avoid freeze/thaw cycles. 

Scientific Category:
Immunotherapy, Metabolic enzyme
Product Type:




Protocol


Assay Kit

 

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