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BPS ▼TPH1 Inhibitor Screening Assay Kit

BPS ▼TPH1 Inhibitor Screening Assay Kit

브랜드 BPS
품명 TPH1 Inhibitor Screening Assay Kit
CAT. NO 72053 분류 assay kit
규격 96 reactions 재고 -
소비자가(₩) 1,530,000 CAS. NO
온도 -80℃ -20℃ R.T. 위험물
수입발주일 목요일 오후 5시
주의사항
Background:
Tryptophan 5-hydroxylase 1 and 2 (TPH1 and TPH2) are enzymes that catalyze the monooxygenation of tryptophan to 5-hydroxytryptophan (5-HTP) which is subsequently converted to serotonin. By catalyzing the rate-limiting step in the biosynthesis of serotonin, these enzymes also play key roles in the signaling of other neurotransmitters downstream of serotonin synthesis, like melatonin. Additionally, TPH enzymes may play a role in immune regulation through tryptophan depletion.
Deion:
The TPH1 Assay Kit is designed to measure TPH1 enzyme inhibition in a 96 reaction format. This fluorescence-based assay kit is especially suitable for high throughput screening applications. The procedure is quick, straightforward, and simple - just mix two solutions, incubate, add quenching solution, and measure the fluorescence.
Synonym(s):
tryptophan 5-hyrdoxylase, TRPH
Format:

COMPONENTS:

Instructions for use:
See product datasheet for detailed protocol.
Storage / Stability:
At least 6 months from date of receipt when stored as directed.
Application(s):
Great for screening small molecular inhibitors for drug discovery and HTS applications.
Reference(s):

1. Moran G. R., et al. J. Biol. Chem. 1998; 273:12259-12266. 
2. Nowak E. C., et al., J. Exp. Med. 2012; 209:2127-2135.

Notes:
MATERIALS REQUIRED BUT NOT SUPPLIED: 
Microplate reader capable of measuring Fluorescence
Warning(s):
Avoid freeze/thaw cycles.
Scientific Category:
Metabolic Enzyme, Immunotherapy
Product Type:




Protocol


Assay Kit

 

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