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BPS ▼TPH1 Inhibitor Screening Assay Kit


BPS ▼TPH1 Inhibitor Screening Assay Kit	브랜드	BPS
	품명	TPH1 Inhibitor Screening Assay Kit
	CAT. NO	72053	분류	assay kit
	규격	96 reactions	재고	-
	소비자가(₩)		CAS. NO
	온도	-80℃ -20℃ R.T.	위험물
	수입발주일	목요일 오후 5시
	주의사항

Background:

Tryptophan 5-hydroxylase 1 and 2 (TPH1 and TPH2) are enzymes that catalyze the monooxygenation of tryptophan to 5-hydroxytryptophan (5-HTP) which is subsequently converted to serotonin. By catalyzing the rate-limiting step in the biosynthesis of serotonin, these enzymes also play key roles in the signaling of other neurotransmitters downstream of serotonin synthesis, like melatonin. Additionally, TPH enzymes may play a role in immune regulation through tryptophan depletion.

Deion:

The TPH1 Assay Kit is designed to measure TPH1 enzyme inhibition in a 96 reaction format. This fluorescence-based assay kit is especially suitable for high throughput screening applications. The procedure is quick, straightforward, and simple - just mix two solutions, incubate, add quenching solution, and measure the fluorescence.

Synonym(s):

tryptophan 5-hyrdoxylase, TRPH

Format:

COMPONENTS:

Instructions for use:

See product datasheet for detailed protocol.

Storage / Stability:

At least 6 months from date of receipt when stored as directed.

Application(s):

Great for screening small molecular inhibitors for drug discovery and HTS applications.

Reference(s):

1. Moran G. R., et al. J. Biol. Chem. 1998; 273:12259-12266.
2. Nowak E. C., et al., J. Exp. Med. 2012; 209:2127-2135.

Notes:

MATERIALS REQUIRED BUT NOT SUPPLIED:
Microplate reader capable of measuring Fluorescence

Warning(s):

Avoid freeze/thaw cycles.

Scientific Category:

Metabolic Enzyme, Immunotherapy

Product Type:

Protocol

Assay Kit

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