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DUCHEFA ▼G-418 disulphate

DUCHEFA ▼G-418 disulphate

브랜드 DUCHEFA
품명 G-418 disulphate
CAT. NO G0175.0005 분류 Biochemical
규격 5g 재고 STOCK
소비자가(₩) 550,000 CAS. NO
온도 4℃ 위험물 수입가능한 위험물
수입발주일 매주 월요일 오전
주의사항

G-418 disulphate 

CAS number 108321-42-2
Molecular weight C20H40N4O10.2H2SO4 = 692.7
Assay :> 650 microg / mg

  

Information

G-418 is an aminoglycoside antibioticum and is applied as a ive agent in transformation experiments. The antibioticum binds to the 30S subunit of the prokaryotic ribosome, thereby inhibiting protein synthesis as well as generating errors in the tranion of the genetic code. Ribosomes of mitochondria and chloroplasts of higher plants are related to bacterial ribosomes and are also susceptible to aminoglycosides. Being a derivative of gentamycin, the antibioticum contains a additional 3’OH that can be phosphorylated by NPT II. As a result of this phosporylation, the charge and the steriometric conformation of the G-418 molecule changes in such a way that the antibioticum is no longer capable of binding to the specific ribosome binding sites.G-418 is used as an alternative for kanamycin in monocots, e.g., rice, Lolium, Graminea which are highly resistant to the latter. In all cases G-418 was shown to be more effective. This is most probably due to the better binding characteristics of the gentamycine shaped structure of G-418. 
 

Storage condition

  • Store at 2-8 °C
  • Soluble in water
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