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ENZO ▼HO-1 polyclonal antibody

ENZO ▼HO-1 polyclonal antibody

브랜드 ENZO
품명 HO-1 polyclonal antibody
CAT. NO ADI-SPA-895-F 분류 Antibody
규격 1 x 200μg 재고 -
소비자가(₩) 545,000 CAS. NO
온도 -20℃ 위험물
수입발주일 매주 목요일 오후 5시
주의사항

 

Alternative Name:HMOX1, Hsp32, Heat shock protein 32, Heme oxygenase 1
 
Host:Rabbit
 
Immunogen:Recombinant rat HO-1 (Hsp32) lacking the membrane spanning region.
 
UniProt ID:P06762
 
GenBank ID:J02722
 
Species reactivity:Human, Mouse, Rat
Dog, Rabbit, Sheep
 
Applications:Flow Cytometry, ICC, IHC (PS), WB
 
Recommended Dilutions/Conditions:Western Blot (1:1,000, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~32kDa by Western blot.
 
Purity Detail:Protein A affinity purified.
 
Formulation:Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:

Heme Oxygenase-1 (HO-1) also known as Hsp32, is the inducible isoform of heme oxygenase that catalyzes the NADPH, oxygen, and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, ferrous iron and biliverdin which is rapidly reduced to bilirubin. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator and has been implicated to be a physiological regulator of cGMP and vascular tone; biliverdin and its product bilirubin are potent antioxidants; "free" iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferring receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5- or 3- UTRs of the mRNAs. To date, three identified heme oxygenase isoforms are part of the HO system that catalyze heme into biliverdin and carbon monoxide. These are inducible HO-1 or Hsp32, constitutive HO-2 that is abundant in the brain and testis, and HO-3 which is related to HO-2 but is the product of a different gene. The HO system is the rate-limiting step in heme degradation and HO activity decreases the levels of heme which is a well known potent catalyst of lipid peroxidation and oxygen radical formation.

 

 




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