Information

SH2-containing 5`-inositol phosphatase 2 (SHIP2) is a lipid phosphatase which converts PI(3,4,5)P₃ to PI(3,4)P₂ in the negative regulation of insulin signaling with the fundamental impact on the state of insulin resistance. SHIP2 down-regulates insulin signaling and is present at higher levels in diabetes and obesity. Abnormalities in SHIP function are increasingly linked to disease, in particular in the role of SHIP as a negative regulator of cytokine and immune receptor signalling.

Tech Data Sheet - TDS E-1000 SHIP2 Rev 3