Information

Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in the mitochondria. ively blocks oxidative stress-induced necrotic cell death (0.1μM NecroX^™-5 prevented ~50% cell death in H9C2 cells exposed to 400μM t-BuOOH for 2 hours LDH assay used). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro, as well as CCl₄ -induced acute liver injury and chronic liver fibrosis in rodent models.