Imuno-oncology(anti cancer immunotherapy)는 암 치료를 위해 환자 자신의 면역계를 사용하는 것을 말합니다.

ENZO lifscience는 immuno-oncology 분야에 관련한 다양한 antibody, ELISA kit, recombinant protein 등을 제공하고 있습니다.

자세한 내용은 아래를 참고해 주시길 바랍니다.

Fighting Cancer with the Immune System

Immuno-oncology, also named cancer immunotherapy, refers to the use of a patient’s own immune system for the treatment of cancer. Over the past decade, research about the role of the immune system in controlling tumorigenesis and tumor progression showed that tumor-infiltrating lymphocytes (TILs) in cancer tissue, and in particular, the presence of CD8+ cytotoxic T cells and the ratio of CD8+ effector T cells/CD4+/forkhead box P3+ regulatory T cells (Tregs), seem to correlate with improved prognosis and long-term survival in many solid tumors. However, activation of T cells requires two signals: 1) recognition of the antigenic peptide/major histocompatibility complex (MHC) by the T cell receptor (TCR) and 2) antigen-independent co-stimulation induced by interactions between co-signaling molecules expressed on antigen-presenting cells (APCs) and their T cell-expressed receptors. T cell activation can also be negatively regulated by co-inhibitory molecules present on APCs, called immune checkpoints, which represent a crucial mechanism for maintaining self-tolerance and regulating the duration and magnitude of immune responses under normal conditions. T cells with a diverse TCR repertoire permanently circulate in the body patrolling for evidence of foreign peptides presented on the surface of cells because of infection or cancer. When a T cell encounters a tumor antigen, this normally results in activation, clonal proliferation/expansion, and a cytolytic response. However, tumor immune interactions may be dysfunctional because of impaired antigen recognition or a highly immunosuppressive microenvironment the tumor creates which eventually leads to immune evasion. 
Drug treatment targeting various mechanisms of immune tolerance and combinations thereof have already been approved by the health authorities and are still being actively investigated. Most immunotherapeutic agents currently in development may be roughly categorized into: (1) drugs targeting the tumor immune evasion via blockade of negative regulatory signals (e.g., co-inhibitory checkpoints) and (2) agents that directly stimulate immunogenic pathways (e.g., agonists of costimulatory receptors). Additional immunostimulatory strategies include enhancers of antigen presentation (e.g., vaccines), the use of exogenous recombinant cytokines, oncolytic viruses, and cell therapies using native or modified antigen-competent immune cells. At Enzo, our aim is to support yours. We have called upon our diverse scientific and technical expertise to create innovative assays and reagents to help support cancer discovery into the next decade, and beyond. We are continually focused on enabling a future with more hope, more collaboration, more discovery, and less disease. 

Targeting Immune Tolerance via Co-Inhibitory Immune Checkpoints